Antibody durability at 1 year after Sputnik V vaccination

SANCHEZ, LAUTARO; OVIEDO ROUCO, SANTIAGO; PIFANO, MARINA; OJEDA, DIEGO S; PASCUALE, CARLA A; MAZZITELLI, BIANCA; DI DIEGO GARCIA, FACUNDO; GONZALEZ LOPEZ LEDESMA, MARÍA M; RODRIGUEZ, PAMELA E; MIGLIETTA, ESTEBAN A; CEBALLOS, ANA; ROSSI, ANDRÉS H; KREPLAK, NICOLAS; GEFFNER, JORGE; GAMARNIK, ANDREA V

LANCET INFECTIOUS DISEASES

ELSEVIER SCIENCE INC

Año: 2022 vol. 22 p. 589 - 590

1473-3099

We used 400 paired serum samples (100 samples at each timepoint, including at baseline before vaccination) from 100 volunteers who received two doses of Sputnik V that were obtained between Jan 1, 2021, and Jan 15, 2022. Participants with current or previous SARS-CoV-2 infection, determined by assessing seropositivity to nucleocapsid protein, were excluded from the analysis. The geometric mean (GM) of international units of IgG anti-spike antibodies2 per mL (IU/mL) were 994 (95% CI 769–1285) at 42 days, 80 (60–106) at 180 days, and 36 (27–47) at 360 days after completion of the two-dose vaccination scheme (figure A; appendix p 2). Overall, a 27-fold reduction in IgG was observed 1 year after Sputnik V vaccination.