1. Potential of liposome-entrapped aminolevulinic acid in cancer therapy. Effect of prior injection of empty liposomes and different routes of administration.

FUKUDA, HAYDÉE; PAREDES, SERGIO; ADRIANA GABRIELA CASAS; CHUEKE, FLORENCIA; BATLLE A

CANCER JOURNAL

LIPPINCOTT WILLIAMS & WILKINS

Lugar: Philadelphia; Año: 1992 vol. 5 p. 295 - 299

1528-9117

The potential use of a liposome-encapsulated porphyrin precursor, delta aminolevulinic acid (ALA), for diagnosis and treatement of malignancies was evaluated.With this aim, in vivo porphyrin synthesis by tumor and other tissues from mammary adenocarcinomabearing mice, receiving liposome-encapsulated ALA by ip and intratumoral routes and with or without previous injection of unloaded liposome vesicles, at different times over 24 hs after injection, was examined.It was found that adminsitration of empty liposomes anhanced the levels of porphyrins accumulated in tumor when ALA was injecred either ip or it. Rapid celarance of porphyrins occurred, so, 24 h after injection of ALA, basal levels were found in almost all tissues axamined.These results, together with the fact that a tumor to skin porphyrin concentration ratio as high as 28 was obtained, supporting our proposal for the use of liposome-entrapped ALA for early diagnosis and phototherapy of malignant cells.