Neural Correlates of Approach-Avoidance Conflict in the Prelimbic Prefrontal Cortex

FERNANDEZ LEON, J.A.; ENGELKE, D.S.; AQUINO-MIRANDA, G.; DO-MONTE, F.H.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

NLM (Medline)

Año: 2020 vol. 45 p. 278 - 382

Background: The ability to identify and discriminate cues associated with reward and aversive stimuli allows an organism to select the most appropriate behavioral response. Neurons in the prelimbic subregion of the prefrontal cortex (PL) respond to both reward- and threat-associated cues. However, whether PL activity regulates the animals’ decision to approach or avoid such cues remains unknown.