Hypothermia Prevents Retinal Damage Generated by Optic Nerve Trauma in the Rat

MANUEL REY-FUNES, IGNACIO M. LARRAYOZ, DANIELA S. CONTARTESE, MANUEL SOLIÑO, ANIBAL SAROTTO, MARTÍN BUSTELO, MARTÍN BRUNO, VERÓNICA B. DORFMAN; CESAR FABIAN LOIDL; ALFREDO MARTINEZ

Scientific Reports

Nature

Año: 2017

2045-2322

Ocular and periocular traumatisms may result in loss of vision. Hypothermia provides a benefcialintervention for brain and heart conditions and, here, we study whether hypothermia can preventretinal damage caused by traumatic neuropathy. Intraorbital optic nerve crush (IONC) or shammanipulation was applied to male rats. Some animals were subjected to hypothermia (8°C) for 3hfollowing surgery. Thirty days later, animals were subjected to electroretinography and behavioraltests. IONC treatment resulted in amplitude reduction of the b-wave and oscillatory potentials of theelectroretinogram, whereas the hypothermic treatment signifcantly (p