INVESTIGADORES
BEKINSCHTEIN Pedro Alejandro
artículos
Título:
Dopamine Modulates Adaptive Forgetting in Medial Prefrontal Cortex
Autor/es:
GALLO, FRANCISCO; MARÍA BELÉN ZANONI; SILVA, AZUL; MORICI, JUAN FACUNDO; MIRANDA, MAGDALENA; MICHAEL ANDERSON; WEISSTAUB, NOELIA V.; BEKINSCHTEIN, PEDRO
Revista:
JOURNAL OF NEUROSCIENCE
Editorial:
SOC NEUROSCIENCE
Referencias:
Lugar: Washington; Año: 2022
ISSN:
0270-6474
Resumen:
Active forgetting occurs in many species, but how behavioral control mechanisms influence which memories are forgotten remains unknown. We previously found that when rats need to retrieve a memory to guide exploration, it reduces later retention of other competing memories encoded in that environment. As with humans, this retrieval-induced forgetting relies on prefrontal control processes. Dopaminergic input to the prefrontal cortex is important for executive functions and cognitive flexibility. We found that, in a similar way, retrieval-induced forgetting of competing memories in male rats requires prefrontal dopamine signaling through D1 receptors. Blockade of medial prefrontal cortex D1 receptors as animals encountered a familiar object impaired active forgetting of competing object memories as measured on a later long-term memory test. Inactivation of the ventral tegmental area produced the same pattern of behavior, a pattern that could be reversed by concomitant activation of prefrontal D1 receptors. We observed a bidirectional modulation of retrieval-induced forgetting by agonists and antagonists of D1 receptors in the medial prefrontal cortex. These findings establish the essential role of prefrontal dopamine in the active forgetting of competing memories, contributing to the shaping of retention in response to the behavioral goals of an organism.