Potential interactions between an oral fosfomycin formulation and feed or drinking water: Impact on bioavailability in piglets

DECUNDO, JULIETA M.; DIÉGUEZ, SUSANA N.; AMANTO, FABIÁN A.; MARTÍNEZ, GUADALUPE; PÉREZ GAUDIO, DENISA S.; FERNÁNDEZ PAGGI, MARÍA B.; ROMANELLI, AGUSTINA; SORACI, ALEJANDRO L.

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS

WILEY-BLACKWELL PUBLISHING, INC

Año: 2021 p. 1 - 10

0140-7783

Feed and drinking water are the most frequently used vehicles for administration ofantibiotics in intensive pig production. Interactions of drugs with feed and water components may affect dissolution and bioavailability. Therefore, antibiotic formulationsshould be tested in order to assure their suitability for oral use. In this study, an oralfosfomycin (FOS) formulation was evaluated considering dissolution in water (soft andhard), release kinetics from feed in simulated gastrointestinal fluids and bioavailabilityafter oral administration blended into feed or dissolved in water (soft and hard), tofed and fasted piglets. FOS reached immediate dissolution in soft and hard water. Thepresence of feed significantly decreased antibiotic dissolution in simulated intestinalmedium. Bioavailability was lower when feed was used as a vehicle for FOS administration than when the drug was dissolved in water (soft or hard). The fed or fastedcondition of piglets did not affect bioavailability. Probably, FOS interactions with feedcomponents alter its dissolution in the gastrointestinal tract, and only a fraction of thedose would be available for absorption. This information must be considered to support decisions on eligibility of antibiotic pharmaceutical formulations and the vehiclefor their administration in order to pursue a responsible use of antibiotics.