INVESTIGADORES
AGUIRRE PRANZONI Celeste Beatriz
artículos
Título:
Coumarin metabolic routes in Aspergillus spp.
Autor/es:
CELESTE AGUIRRE-PRANZONI; ALEJANDRO A. ORDEN; FABRICIO R. BISOGNO; CARLOS E. ARDANAZ; CARLOS E. TONN; MARCELA KURINA-SANZ
Revista:
fungal biology
Editorial:
ELSEVIER
Referencias:
Año: 2011 vol. 115 p. 245 - 252
ISSN:
1878-6146
Resumen:
Coumarin metabolism by several Aspergillus strains was studied. Aspergillus ochraceus and
Aspergillus niger carried out the reduction of the C3eC4 double bond to yield dihydrocoumarin
in 24 h. Meanwhile, the first strain did not transform dihydrocoumarin after 7 d,
A. niger demonstrated to have two divergent catabolic pathways: (a) the lactone
moiety opening and further reduction of the carboxylic acid furnishing the primary alcohol
2-(3-hydroxypropyl)phenol and, (b) the hydroxylation of the aromatic ring of dihydrocoumarin
at a specific position to give 6-hydroxy-3,4-dihydrochromen-2-one. Aspergillus flavus
did not perform double bond reductions, and only produced oxygenated metabolites,
mainly 5-hydroxycoumarin. Enzyme-specific inhibitors and a coumarin analogous were
useful to confirm the A. niger catabolic route.