Two drimane lactones, valdiviolide and 11-epivaldiviolide, in the form of a 1:1 cocrystal obtained from Drimys winteri extracts

CRISTIAN PAZ ROBLES; DARIO MERCADO; SEBASTIAN SUAREZ; RICARDO BAGGIO

ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS

WILEY-BLACKWELL PUBLISHING, INC

Lugar: Londres; Año: 2014

0108-2701

The species herein presented, formulated as C15H22O3 (I) was obtained from Drimys winteri, and appears as a co-crystallization of two isomeric drimane sesquiterpene lactones, valdiviolide (Ia) and 11-epivaldiviolide (Ib), none of which had been individually reported in crystal form. Both isomers present three quiral centres at sites 5,10 and 11, with a (SSR)/(SSS) sequence in (Ia/Ib), respectively. O?H···O bonds bind molecules into chains running along [120], in turn linked by π···π staking interactions to define planar, weakly interacting arrays parallel to (001)