INVESTIGADORES
SOMOZA Gustavo Manuel
artículos
Título:
Inhibition by naloxone of the serotonin-induced prolactin release in free-moving rats.
Autor/es:
GUSTAVO M SOMOZA; GUSTAVO LARREA; DAMASIA BECÚ,; DANIEL CARDINALI; CARLOS LIBERTUN,; GUSTAVO M SOMOZA
Revista:
JOURNAL OF NEURAL TRANSMISSION. GENERAL SECTION.
Editorial:
SPRINGER WIEN
Referencias:
Año: 1983 vol. 56 p. 97 - 102
ISSN:
0300-9564
Resumen:
The effect of the opiate antagonist naloxone on serum prolactin aftertreatment with serotonin, arginine vasotocin (AVT) or melatonin was studiedin prepubertal and adult unanesthetized rats. Prolactin was quantifiedin blood samples withdrawn through an intrajugular silastic cannula fromundisturbed ovariectomized adult rats.After taking a basal sample, animals were injected through the cannulawith naloxone (0.8 mg/kg) and 5 min later with serotonin creatinine sulphate(6.4 mg/kg), AVT (20/~g/kg), melatonin (4 mg/kg) or saline; newsamples were taken 15 and 30 min thereafter. Injection ofserotonin was followedby a 10-fold increase of prolactin levels 15 min later; this increase wasdrastically reduced, although not abolished, by pretreatment with naloxone.In animals injected with saline, AVT or melatonin, no significant changes inserum prolactin were observed.In a second group of experiments, 30 day-old female rats injected withserotonin creatinine sulphate (10 mg/kg, i.p.) exhibited a &fold increase inserum prolactin 15 rain after injection; this increment was reduced but notabolished by pretreatment with naloxone (5 mg/kg, i.p.).It is postulated that the prolactin releasing effect of serotonin is mediated,at least in part, by an opioid receptor.