INVESTIGADORES
D`ALESSIO Luciana
congresos y reuniones científicas
Título:
Analysis of risk factor for postictal and interictal psychosis in patients with refractory epilepsy
Autor/es:
D`ALESSIO L, GIAGANTE B, IBARRA V, PAPPAYANNIS C, ODDO S, SOLIS P, SALGADO P,
Lugar:
Paris
Reunión:
Congreso; 26th International Epilepsy Congress; 2005
Institución organizadora:
Liga Internaciona contra la Epilepsia
Resumen:
Introduction Epileptic patients are at higher risk for acute and chronic psychotic states. Objectives In this study we analyzed the presence of risk factors for developing Postictal Psychosis (PIP) and Interictal Psychosis (IP). Methods 113 consecutive patients with refractory epilepsy were evaluated. 82 % of them had temporal origin. All patients underwent complete neurological, neuroimaging, neuropsychological, and psychiatric assessment. Clinical, demographic, psychiatric, neuropsychological, and neuroimaging data were assessed by logistic regression.  Results Twenty-four percent of patients had a positive history for PIP and thirty eight percent had IP psychosis. Fifty one percent did not show any type of psychosis. Epilepsy time duration, presence of febrile seizures history, and the absence of experiential aura were significantly more frequent in patients with PIP (p¡Ü 0.05). Eight percent of patients with temporal lobe epilepsy had bilateral hippocampal sclerosis in the MRI, and 62% of them had PIP and 75 % IP (p¡Ü 0.05 compared with patients with no history of psychosis). The presence of hippocampal sclerosis plus in RMN was associated with the absence of PIP history (p¡Ü 0.05). Conclusions Postictal psychosis was more common in patients with longer epilepsy duration, febrile seizure history, and absence of experiential auras. The presence of bilateral hippocampal sclerosis was associated with both PIP and IP. Other features associated with IP were not found. Risk factors for PIP seem to be more distinctiveness than those for IP.