INVESTIGADORES
SOMOZA Gustavo Manuel
artículos
Título:
Serotonin stimulates gonadotropin release in female and male goldfish
Autor/es:
GUSTAVO M SOMOZA; KEI L YU; RICHARD E PETER; GUSTAVO M SOMOZA
Revista:
GENERAL AND COMPARATIVE ENDOCRINOLOGY
Editorial:
ACADEMIC PRESS INC ELSEVIER SCIENCE
Referencias:
Año: 1988 vol. 72 p. 364 - 382
ISSN:
0016-6480
Resumen:
Effects of serotonin (5-HT) on serum gonadotropin (GtH) levels were studied in femaleand male goldfish, Carassius auratus L. Intraperintoneal (ip) administration of 5-HT (10kg/g) produced a significant increase in serum levels of GtH at 0.5, 1, and 2 hr but not at 3-4hours, after the drug was injected. Adminstration of different concentrations of 5-HT intothe brain third ventricle (iv) did not affect serum GtH levels. In both sexes, the intraperitonealadministration of different doses of 5-HT (2.5-20 pgig) caused a dose-dependentincrease in serum GtH levels in fish at different gonadal stages; the greatest responsesoccurred in mature (= prespawning) fish. Fluoxetine (10 pgig; ip), a S-HT reuptake inhibitor,potentiated the stimulatory effects of .5-HT on GtH secretion. Ketanserin (10 p,g/g; ip), a5-HT antagonist, did not modify basal GtH levels; however, ketanserin blocked the 5-HTinduced release of GtH. These results indicate that 5-HT has a stimulatory effect on GtHrelease in goldfish, most likely at the level of the pituitary gland.