INVESTIGADORES
BONGIOVANNI Guillermina Azucena
artículos
Título:
Multielemental mapping and arsenic determination in organs of rats by SR-µXRF
Autor/es:
PEREZ, RD; RUBATTO BIRRI, PN; PEREZ, CA; RUBIO, M; BONGIOVANNI, GUILLERMINA
Revista:
ActivutyReport
Editorial:
ABTLuS (Asociación Brasilera de Tecnología de Luz Síncrotron)
Referencias:
Año: 2006 vol. 1
ISSN:
1518-0204
Resumen:
Arsenic is a naturally occurring element widely present in
the environment. Inorganic arsenic exposure in humans is
causally associated with development of malignancies in various
tissues, including the skin, liver, urinary bladder, lung and
prostate. It has been reported gastrointestinal, hematological,
hepatic, renal, dermal, neurological, reproductive pathologies
and other effects in humans due to ingestion of heavy doses,
sub-acute poisoning or repeated exposures to low concentrations
of arsenic [1, 2]. Several areas of Argentina have had
high exposures to arsenic from naturally contaminated drinking
water, particularly the eastern region of the province of
C¨®rdoba [3, 4]. The disease ascribed to arsenic contamination
in Argentina was called Chronic Endemicregional Hydroarsenism
(HACRE, Hidroarsenicismo Cr¨®nico Regional
End¨¦mico, in spanish) [5]. Although arsenic is a recognized
human carcinogen, the mechanism by which arsenic induces
cancer is unknown, in large part due to the lack of an appropriate
animal model. Since the effect of arsenic may be due
to its longer retention in certain tissues, information on the
tissue dosimetry of the organic arsenicals after exposure to inorganic
arsenic, as well as in vivo toxicology studies, are of
critical importance. In this study, groups ofWistar rat received
drinking water containing sodium arsenite (NaAsO2) at 0 and
55 ppm. arsenic ad libitum from days 50 to 110 after birth
and then, the spatial distribution of metals was determined in
brain, pancreas, kidney and liver by ¦Ì-SRXRF
and then, the spatial distribution of metals was determined in
brain, pancreas, kidney and liver by ¦Ì-SRXRF
and then, the spatial distribution of metals was determined in
brain, pancreas, kidney and liver by ¦Ì-SRXRF
and then, the spatial distribution of metals was determined in
brain, pancreas, kidney and liver by ¦Ì-SRXRF
55 ppm. arsenic ad libitum from days 50 to 110 after birth
and then, the spatial distribution of metals was determined in
brain, pancreas, kidney and liver by ¦Ì-SRXRF
and then, the spatial distribution of metals was determined in
brain, pancreas, kidney and liver by ¦Ì-SRXRF
and then, the spatial distribution of metals was determined in
brain, pancreas, kidney and liver by ¦Ì-SRXRF
and then, the spatial distribution of metals was determined in
brain, pancreas, kidney and liver by ¦Ì-SRXRF
55 ppm. arsenic ad libitum from days 50 to 110 after birth
and then, the spatial distribution of metals was determined in
brain, pancreas, kidney and liver by ¦Ì-SRXRF
and then, the spatial distribution of metals was determined in
brain, pancreas, kidney and liver by ¦Ì-SRXRF
and then, the spatial distribution of metals was determined in
brain, pancreas, kidney and liver by ¦Ì-SRXRF
and then, the spatial distribution of metals was determined in
brain, pancreas, kidney and liver by ¦Ì-SRXRF
55 ppm. arsenic ad libitum from days 50 to 110 after birth
and then, the spatial distribution of metals was determined in
brain, pancreas, kidney and liver by ¦Ì-SRXRF
and then, the spatial distribution of metals was determined in
brain, pancreas, kidney and liver by ¦Ì-SRXRF
and then, the spatial distribution of metals was determined in
brain, pancreas, kidney and liver by ¦Ì-SRXRF
and then, the spatial distribution of metals was determined in
brain, pancreas, kidney and liver by ¦Ì-SRXRF
2) at 0 and
55 ppm. arsenic ad libitum from days 50 to 110 after birth
and then, the spatial distribution of metals was determined in
brain, pancreas, kidney and liver by ¦Ì-SRXRF
and then, the spatial distribution of metals was determined in
brain, pancreas, kidney and liver by ¦Ì-SRXRF
and then, the spatial distribution of metals was determined in
brain, pancreas, kidney and liver by ¦Ì-SRXRF
and then, the spatial distribution of metals was determined in
brain, pancreas, kidney and liver by ¦Ì-SRXRF
ad libitum from days 50 to 110 after birth
and then, the spatial distribution of metals was determined in
brain, pancreas, kidney and liver by ¦Ì-SRXRF¦Ì-SRXRF