Gastrointestinal effects of Solidago chilensis and development of a dry plant extract with adequate physico-mechanical properties.

BUCCIARELLI ALEJANDRO; GALLO LOREANA; MILCZAKOWSKYG MARÍA; SKLIAR MIARIO

Rosario

Congreso; 41ª Reunión Anual de SAFE; 2009

Sociedad Argentina de Farmacología Experimental (SAFE)

Solidago chilensis Meyen (Asteraceae) is a native species from South America, widely used in the popular medicine of different countries as an anti-inflammatory, diuretic and to treat  gastrointestinal disorders. Despite its traditional uses, pharmacological and toxicological investigations are rather scarce. Gastroprotective effect on ethanol-induced gastric ulcer model and gastrointestinal transit on charcoal meal test of the aqueous plant extract were evaluated in mice. S. chilensis extract exhibited a significant reduction in both gastric ulceration and gastrointestinal transit at 1000 and 2000 mg/kg doses. Acute toxicity by means of a functional observational battery and by assessing the motor activity in an open field was evaluated in mice. No toxic effects were observed for exposure to the extract. Taking into account the possible therapeutical use of the plant, a novel dry plant extract (NDPE) of S. chilensis was developed and physico-mechanical properties were studied. NDPE showed acceptable flow properties for direct compression (DC). Pharmacological results and physico-mechanical properties exhibited by NDPE might be useful in the development of a suitable oral dosage form towards the treatment of gastric ulcers and related disorders by means of DC technology.