Design of Valeriana officinalis tablets using a coprocessing dry plant extract

GALLO LOREANA; BUCCIARELLI ALEJANDRO; CASTRO SILVINA; PIÑA JULIANA; BUCALA VERÓNICA; SKLIAR MARIO; PALMA SANTIAGO; ALLEMANDI DANIEL

Tandil

Congreso; CUADRAGÉSIMA REUNION ANUAL DE SAFE; 2008

Sociedad Argentina de Farmacología Experimental

Many people suffer sleep problems, and consumed benzodiazepines to resolve this pathology, about this it have been reported that V. officinalis L. (Valerianacea) possesses hypnotic activity and few adverse effects. A solid pharmaceutical dosage formulation using a novel dry plat extract (NDPE) of V. officinalis is proposed. The botanical evaluation of the plant material is presented, it permits a correct identification of the species and guarantees a good phytomedicine quality. Physical and mechanical properties of DPE alone and with excipients were studied. Tablets containing a DPE and common excipients were evaluated. V. officinalis DPE possesses suitable rheological properties and compressibility, permitting its use in direct compression. Formulations like: V. officinalis DPE (300mg), Avicel PH101 (146mg), Emcompress (146mg), magnesium stearate (8mg) and V. officinalis DPE (300mg), Avicel PH101 (146mg), Lactose CD (146mg) and magnesium stearate (8mg) showed the best pharmaceutical performance.