INVESTIGADORES
GALLO Loreana Carolina
congresos y reuniones científicas
Título:
Ammonium bicarbonate as a pore-forming agent for the production of porous inhalable particles
Autor/es:
SERAIN MARCOS; BUCALÁ VERÓNICA; GALLO LOREANA
Reunión:
Congreso; 6ta Reunión Internacional de Ciencias Farmacéuticas (RICiFa 2020+1); 2021
Resumen:
Recently, ammonium bicarbonate (AB) has begun to be used to produce porous particles of drugs (sodium cromoglycate and meloxicam) and excipients (mannitol) for inhalatory administration. To this end, AB was incorporated in aqueuos samples avoiding the use of solvents or emulsion systems. AB decomposes in carbon dioxide and ammonia gas at 36 °C producing pores. In the present work, AB was employed in the spray drying of salbutamol sulphate (SS) in order to extend its use to other drugs. Aqueuos solutions of SS alone and containing AB were spray drying at fixed conditions: SS:AB = 1:0 (A), 1:0.5 (B), 1:0.125 (C) and 1:0.0625 (D). The process yield (PY), moisture content (MC), bulk and tap densities and morphology of the particles were evaluated. All the samples showed high PY (70 %), except sample B (15%). The MC values were satisfactory ( 3 %) for all the powders. Samples dried with AB presented densities lower than SS, suggesting the presence of porous. However, the morpholgy of these particles did not show significant porosity. In conclusion, AB does not act as a pore-forming agent for any drug, thus further investigations should be done to understand the effect of AB on SS drying.