Study of the influence of different factors affecting albendazole loading on SBA-15 carrier by Box-Behnken design

ADROVER ESPERANZA; PEDERNERA MARISA; BONNE MAGALÍ; BÉNÉDICTE LEBEAU; BUCALÁ VERÓNICA; GALLO LOREANA

Congreso; 6ta Reunión Internacional de Ciencias Farmacéuticas (RICiFa 2020+1); 2021

Albendazole (ABZ) is an antiparasitic drug that belongs to the BSC II classification. Mesoporous materials loaded with poorly soluble drugs (BSC II) become an interesting strategy to increase their solubility/dissolution rate as the drug crystalline state changes into an amorphous one. However, high drug loading into mesoporous materials still constitutes a challenge. The purpose of this work was to study the influence of different factors affecting ABZ loading on the mesoporous carrier SBA-15: temperature (25, 37.5 and 50 ºC), soaking time (24, 48 and 72 h) and SBA-15 mass (83.2; 167.6 and 252.0 mg). The effect of these factors was analyzed using the Box-Behnken design. The drug loading experiments were done by the immersion method and the amount of loaded ABZ was quantified by elemental analysis. The loading conditions of 37.50 ºC, 24 h, and 83.2 mg SBA-15 allowed the maximum drug loading (35.84 %, w/w). As the SBA-15 mass and soaking time decreases, the percentage of ABZ loading increases. The SBA-15 mass had the highest significant influence on the drug loading. In conclusion, these results show the relevant effect of the loading conditions and consequently the requirement to optimize these parameters.