Production and characterization of co spray-dried drug-polymer microparticles for inhalation: Influence of polymer type on the process yield and product properties.

GALLO, LC; PIÑA J; BUCALÁ V; RAMIREZ RIGO MV

Córdoba

Congreso; 3° Reunión Internacional de Ciencias Farmacéuticas (RICiFa 2014); 2014

Universidad Nacional de Córdoba

Inhalation therapy is used to deliver drugs to the respiratory tract, especially for local diseases. Solid formulations are preferred, being their success dependent on particles characteristics, breathing conditions and mucociliary clearance. Spray-drying is a process that converts liquids into powders. The feasibility of manipulating its operating conditions and the liquid composition allows the optimization of particle characteristics. The aim of this work was the production and characterization of novel spray-dried polymeric microparticles for inhalatory administration and sustained delivery of an antiasthmatic drug. Sodium cromoglicate (SC) and mucoadhesive polymers, namely carboxymethylcellulose (CMCNa), alginate (AlgNa) and hyaluronate (HLNa) sodium salts, were employed. These polymers may modulate the drug delivery and particles? residence time. At fixed operating conditions, previously selected, SC:polymer (1:0.16) aqueous solutions were spray-dried. The process yield (PY) was gravimetrically measured. Many particles characteristics, such as moisture content (MC), mean volumetric diameter (D4,3), size distribution width (span factor), density (Dp), morphology and estimated aerodynamic diameter (Daer), were evaluated. Significant effects were determined using ANOVA. Table 1 presents the obtained results. Statistically analysis showed that the liquid formulation had a significant effect (p0.05). All the Daer were lower than 8.25 μm, appropriate sizes for inhalatory administration. Additionally, all the span factors (< 2) indicated narrow distributions. The SC:HLNa powder showed the best attributes for the desired application (lowest Daer and span). The selected drying conditions and formulation allowed the production of SC-polymer particles with appropriate Daer, span, MC and acceptable PY for inhalation