Thermoresponsive hydrogels from alginate-based graft copolymers

M.M.S. LENCINA; Z. IATRIDI; M.A. VILLAR; C. TSITSILIANIS

EUROPEAN POLYMER JOURNAL

PERGAMON-ELSEVIER SCIENCE LTD

Lugar: Amsterdam; Año: 2014 vol. 61 p. 33 - 44

0014-3057

Three samples of sodium alginate grafted by amino-terminated PNIPAM (low and high molecular weight poly(N-isopropylacrylamide)) and a random P(NIPAM-co-NtBAM) (NtBAM: N-tertiary butyl acrylamide) copolymer, were synthesized via the carbodiimide chemistry and their temperature-induced hydrogelation capability was evaluated by rheology. All the samples showed thermothickening behaviour depending on concentration, ionic strength and hydrophobic comonomer content, incorporated to the PNIPAM thermo-sensitive pendant chains. The main result of this study was that a slight hydrophobic enrichment (just 15 mol% NtBAM) of PNIPAM was sufficient to shift the gelation temperature well below the physiological temperature at 32 C and at the lowest polymer concentration studied (i.e. 10 wt%). The consequence of that was that the ALG-g-P(NIPAM-co-NtBAM) graft copolymer hydrogel exhibited the best rheological thermoresponsive properties and might be used as injectable hydrogel for potential applications in biomedicine.