Large-Scale Metabolic Network Design under Stability Constraints for Sustainable Biofuel Production

J. DI MAGGIO; A. BLANCO; A. BANDONI; S. DÍAZ

Buenos AIres

Congreso; ALIO-INFORMS International Meeting; 2010

“Large-Scale Metabolic Network Design under Stability Constraints for Sustainable Biofuel Production”. J. Di Maggio, A. Blanco, A. Bandoni, S. Diaz; ALIO-INFORMS International Meeting; paper No. 1, MA11, p.51. Buenos Aires, June 6-9, 2010.   http://meetings2.informs.org/BuenosAires2010/     Session MA11 - Aula 362- Third Floor Nonlinear Optimization: Algorithms and Applications II Cluster: Nonlinear Optimization Invited Session Chair: Cristina Maciel, Full Professor, Universidad Nacional del Sur, Av. Alem 1253, Bahía Blanca, BA, B8000FWB, Argentina, immaciel@criba.edu.ar     1 - Large-scale Metabolic Network Design Under Stability Constraints for Sustainable Biofuel Production Alberto Bandoni, PLAPIQUI, UNS-CONICET, Argentina, abandoni@plapiqui.edu.ar, Soledad Diaz, Jimena Di Maggio, Anibal Blanco   We propose an eigenvalue optimization approach to ensure steady state stability of the EMP pathway, the PP pathway, phosphotranferase system and fermentation pathways of Escherichia coli to maximize ethanol production. The model consists of 26 differential equations that represent dynamic mass balances of extracellular glucose, intracellular metabolites and fermentation products, 37 kinetic rate expressions and additional correlations for co-metabolites temporal profiles.