INVESTIGADORES
BUCALA Veronica
congresos y reuniones científicas
Título:
Design of Cascara Sagrada tablets by direct compression using a spray dried extract
Autor/es:
GALLO, LOREANA; PORRAS, MAURICIO; LLABOT, JUAN; PIÑA, JULIANA; BUCALÁ, VERÓNICA; ALLEMANDI, DANIEL
Lugar:
Cordoba
Reunión:
Congreso; 1º Reunión Internacional de Ciencias Farmacéuticas; 2010
Institución organizadora:
UNC, Fac. de Cs. Qcas., Dpto Farmacia
Resumen:
Pharmaceutical tablets are the principal dosage form for drug delivery, occupying two-thirds of the global market (1). Generally, direct compression (DC) is one of the most advantageous processes for tablet manufacture; it offers several advantages such as simplicity, low processing time and power consumption. On the other hand, the DC primary limitations are good flow properties and compressibility requirements (2).                 In the case of phytomedicine tablets, the active component is a dry plant extract (DPE). Usually, DPEs have poor flow properties and compactability and consequently they cannot be utilized for DC (3).                 Sprays dryers are the most common technique used in the herbal processing industries. One of the main reasons is the ability to generate a product with precise quality specifications in continuous operations. The most normally required product specifications are moisture content, flow properties and hygroscopicity (4).                 The goal of this study was to optimize the attainment of a vegetal solid extract (SDE) with suitable flow and compression characteristics in order to develop tablets containing Cáscara sagrada solid extract as active component. The spray drying process was selected as method for the SDE attainment and the composition of tablet formulae was proposed. The pharmaceutical performance of the formulation was evaluated.