Characterization of Indomethacin Microparticles for Inhalatory Administration

CESCHAN, NAZARETH; GALLO, LOREANA; VERONICA BUCALA; RAMIREZ RIGO, MARÍA VERÓNICA

Sheffield

Workshop; 7th International Granulation Workshop; 2015

Sheffield University

The inhalatory administration is an alternative drug administration route for local and systemic treatments. Indomethacin (a non-steroidal anti-inflammatory drug) is an interesting candidate to be delivered by the pulmonary route due to its gastrolesive and oral bioavailability problems. Among other technologies, the spray drying allows to obtain particulate systems suitable for inhalatory administration by the proper manipulation of the process operating variables as well as the liquid feed formulation. Co-processed microparticles based on indomethacin, polylysine and dextrin were obtained by spray drying. In this work, the aerolization performance of the obtained powders was evaluated by the assessment of the aerodynamic size distribution in a next generation impactor (NGI). The results proved that the developed formulation became suitable for pulmonary administration. Also, the median aerodynamic size evaluated by using a NGI was compared to an estimation of the median aerodynamic size based on the analysis of the particle size distribution by laser diffraction and the skeletal particle density assessed by nitrogen adsorption. This last method, which is a relatively much less laborious procedure, was found to be conservative to estimate the median aerodynamic size and therefore can be used for formulations screening.