Design of Valeriana Officinalis Tablets using a Coprocessing Dry Plant Extract

GALLO, LOREANA; BUCCIARELLI, ALEJANDRO; CASTRO, SILVINA; PIÑA, JULIANA; BUCALÁ, VERÓNICA; SKLIAR, MARIO; PALMA, SANTIAGO; ALLEMANDI, DANIEL

Tandil, Argentina.

Otro; XL Congreso de la Sociedad Argentina de Farmacología Experimental (SAFE),; 2008

Sociedad Argentina de Farmacología Experimental

Many people suffer sleep problems, and consumed benzodiazepines to resolve this pathology, about this it have been reported that roots and rhizomes of Valeriana officinalis (Valerianacea) possesses hypnotic activity and few adverse effects in comparison with synthetic drugs. A solid pharmaceutical dosage formulation using a novel dry plat extract (NDPE) of V. officinalis is proposed. The botanical evaluation of the plant material is presented. This evaluation permits a correct identification of the species and guarantees a good phytomedicine quality. Physical and mechanical properties of DPE alone and with excipients were studied. Several formulations (tablets) containing a NDPE and common excipients for direct compression were evaluated. V. officinalis DPE possesses suitable rheological properties and compressibility, permitting its use in direct compression. The following formulations: V. officinalis DPE (300 mg), Avicel PH101 (146 mg), Emcompress (146 mg), magnesium stearate (8 mg) and the formulation containing V. officinalis DPE (300 mg), Avicel PH101 (146 mg), Lactose CD (146 mg) and magnesium stearate (8 mg) showed the best pharmaceutical performance.