Synthesis and characterization of mesoporous SBA-15 and SBA -16 as carriers to improve albendazole dissolution rate

ESPERANZA ADROVER, MARÍA; PEDERNERA, MARISA; BONNE, MAGALI; LEBEAU, BÉNÉDICTE; VERONICA BUCALA; GALLO, LOREANA

Saudi Pharmaceutical Journal

elsevier

Año: 2019

1319-0164

AbstractAlbendazole (ABZ, anti-parasitic active pharmaceutical ingredient) is a crystallinelow water-soluble drug, thus the dissolution rate in gastrointestinal fluids is limited.Consequently, the improvement of the water solubility and dissolution rate of ABZimplies a great challenge for a more efficient treatment of hydatidosis. In this context,SBA-15 and SBA-16 ordered mesoporous silica materials were synthetized and loadedwith ABZ. X-ray diffraction, FT-IR spectroscopy, nitrogen physisorption manometry,particle size distribution and scanning electronic microscopy were used to characterizeunloaded and loaded materials (ABZ/SBA-15 and ABZ/SBA-16). The loaded ABZamount in the carriers was estimated by elemental analysis. For the loaded materials, thedrug solubility and release profile were evaluated. In addition, mathematical modelswere compared to explain the dissolution kinetics of ABZ from mesoporous solids.ABZ was successfully loaded into the mesopores. The amorphous state of theadsorbed ABZ was confirmed by differential scanning calorimetry that resulted in anotable increment in the dissolution rate compared to crystalline ABZ. Drug releasebehaviors were well simulated by the Weibull model for ABZ/SBA-15 and by theGompertz function for pure ABZ and ABZ/SBA-16. The SBA-15 carrier exhibited thehighest drug loading and dissolution rate becoming a promising material to improveABZ bioavailability.