INVESTIGADORES
BUCALA Veronica
artículos
Título:
Integration of PLGA Microparticles in Collagen-Based Matrices: Tunable Scaffold Properties and Interaction Between Microparticles and Human Epithelial-Like Cells
Autor/es:
GALLO, L.C.; MADAGHIELE, M.; SALVATORE, L.; BARCA, A.; SCIALLA, S.; BETTINI, S.; VALLI, L.; VERRI, T.; VERONICA BUCALA; SANNINO, A.
Revista:
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS
Editorial:
TAYLOR & FRANCIS AS
Referencias:
Año: 2018
ISSN:
0091-4037
Resumen:
The feasibility to obtain highly porous collagen-based scaffolds (SCs) integrated with uniformly dispersed poly(lactide-co-glycolide) (PLGA) microparticles (MPs) was evaluated. PLGA-MPs were prepared by double emulsion technique and SCs with different amounts of MPs (SC/PLGA-MPs) were produced. Results showed that SC/PLGA-MPs could be successfully manufactured, the PLGA-MPs being physically retained in the SCs, without affecting the porous structure. PLGA-MPs also increased the SC hydrophilicity, acted as a mechanical reinforcement and retarded the degradation rate. In addition, the interactions between MPs and Caco-2 cells did not interfere with the correct morphological, adhesion and proliferation pathways.