INVESTIGADORES
CIAPPONI AgustÍn
artículos
Título:
Course of serological tests in treated subjects with chronic Trypanosoma cruzi infection: a systematic review and meta-analysis of individual participant data
Autor/es:
AGUSTÍN CIAPPONI
Revista:
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES : IJID : OFFICIAL PUBLICATION OF THE INTERNATIONAL SOCIETY FOR INFECTIOUS DISEASES.
Editorial:
ELSEVIER SCI LTD
Referencias:
Lugar: Amsterdam; Año: 2018
ISSN:
1201-9712
Resumen:
RESULTS:We included 27 studies (1296 subjects) conducted in eight countries. The risk of bias was low for all domains in 17 studies (63.0%). We assessed 913 subjects (149 seroreversion events, 83.7% censored data) for ELISA, 670 subjects (134 events, 80.0% censored) for IIF, and 548 subjects (99 events, 82.0% censored) for IHA. A higher probability of seroreversion was observed in subjects aged 1-19 years compared to adults at a shorter time span. The chance of seroreversion also varied according to the country where the infection might have been acquired. For instance, the pooled adjusted hazard ratio between children/adolescents and adults for IIF test was 1.54 (95% CI 0.64-3.71) and 9.37 (3.44-25.50) in some countries of South America and Brazil, respectively.