INVESTIGADORES
GONZALEZ paula Natalia
congresos y reuniones científicas
Título:
The generation of variation and developmental constraints in the vertebrate skull.
Autor/es:
HALLGRIMSSON B; YOUNG N.; PAVLICEV M.; MITTEROECKER P.; GONZALEZ P.; MARTINEZ-ABADIAS N.; JAMNIZCKY H.; MARCUSIO R.
Reunión:
Congreso; ICVM; 2013
Resumen:
Pere Alberch¹s paper on developmental constraints in the 1982 Dahlem conference volume was influential because it crystalized the developmental constraint concept for so many evolutionary biologists. In this paper, he imagined a discontinuous phenotype space in which the gaps were determined not just by the adaptive landscape but also by the developmental processes that generate variation. Thirty years later much more is known about the mechanisms that generate and structure the expression of phenotypic variation. Evolutionary developmental biology has also matured in this time and concepts such as modularity , integration and novelty have become key theoretical anchors for the field. Still, Alberch¹s focus on the generation of variation and, in particular, on the role of development in producing discontinuities in morphospace has tremendous resonance in modern evolutionary developmental biology. Drawing on our work on the collaborative cross mice, various mouse and chick models, human genetics as well as comparative analyses of facial morphogenesis, we show how a focus on the mechanisms that generate phenotypic variation can produce insights into the evolvability of complex morphologies. In this way, Alberch¹s contention that the generation of variation imparts structure on the diversity in nature resonates still with our ongoing work on the evolutionary developmental biology of the vertebrate craniofacial complex.