Physiological role of individual neuropeptides in triatomines in the search of targets for new insecticides

CAPRIOTTI NATALIA; IANOWSKI JUAN P; NICHOLS RUTHANN; ONS SHEILA

Cafayate Argentina

Congreso; Invertebrate Neuropeptide Conference; 2017

International Neuropeptide Society

● Blood meals in Rhodnius prolixus are infrequent but abundant. In approximateminutes nymphs can ingest the equivalent to 10 times their own unfed body win blood.● R. prolixus feeds on blood that is hypo-osmotic to its own hemolymph. Therethe meal poses a considerable threat to homeostasis. Thus, these insects underapid postprandial diuresis that allows the excretion of 50% of the volume ingein 2 hours.● Activation of diuresis is possible because of the excretory activity of the Malpigtubules, the increase on frequency of the contractions in the heart andperistaltic waves in the anterior midgut. Neuropeptides are involved in tprocess.● The design of molecules capable of interfering with the neuroendocrine sydisturbing normal physiology has been proposed as a novel route of the obtaof new insecticides to manage harmful insects.● Here we evaluated the role of the neuropeptides OKA, OKB, CCH-amide and sNthe diuresis and the myoregulatory or cardioregulatory activity of R. prolixus