Synthesis and Antimicrobial Activities of Gold(I) N-heterocyclic Carbene Complexes

GABRIELA FERNÁNDEZ; SOLEDAD VELA GUROVIC; NELDA LILA OLIVERA; ALICIA CHOPA; GUSTAVO SILBESTRI

Conferencia; The 16th International Electronic Conference on Synthetic Organic Chemistry; 2012

Water-soluble gold(I) complexes [1-mesityl-3-(3-sodiumsulfonatopropyl)imidazol-2-ylidene] gold(I) Chloro (3) and [1,3-bis(2,6-diisopropyl-4-sodiumsulfonatophenyl) imidazol-2-ylidene] gold(I) Chloro (4) were prepared, in high yield, by carbene transmetallation from the appropriate NHC silver complex with chloro tetrahydrothiophene gold ([AuCl(tht)]). The antimicrobial properties of both gold(I) compounds and the respective ligands were assessed by agar diffusion assay and the broth macrodilution method against both Gram-positive and negative bacteria. MICs values (> 128 ug/ml) were superior to those displayed by the reference antibiotics penicillin G and streptomycin.