MURRAY Ana paula
congresos y reuniones científicas
Aromatic plants as a potential source of cholinesterase inhibitors
RODRIGUEZ, SILVANA; BELLADONNA, DAMIÁN; RODRIGUEZ, ROBERTO; ANA PAULA MURRAY
Congreso; 6ta Reunión Internacional de Ciencias Farmacéuticas (RICiFa 2020+1) EVENTO VIRTUAL; 2021
The inhibition of the enzymes acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) is relevant for the discovery of new alternatives in the treatment of Alzheimer?s disease. The inhibition of the activity of both AChE and BChE by the essential oils of four aromatic species cultivated at the Southwest of Buenos Aires province Artemisia absinthium (1), Lavandula hybrida (2), Melissa officinalis (3) and Rosmarinus officinalis (4) was studied.The chemical composition of the essential oils obtained from aerial parts by hydrodistillation was determined by gas chromatography-mass spectrometry (GC-MS). Enzymatic inhibition was determined spectrophotometrically by Ellman?s method.The essential oil 3, containing menthol and geraniol as major components, showed the most effective AChE inhibition (IC50 = 50.35 ng/mL). In addition, 1, 2 and 4, containing caryophyllene showed potent AChE inhibition (IC50 = 126.9 - 205.9 ng/mL).On the other hand, 2 presented potent BChE inhibitory activity with IC50 = 35.63 ng/mL, which could be explained by the presence of 1,8-cineole and α- pinene. Also, 1, 3 and 4, containing myrcene showed good BChE inhibition (IC50 = 84.04 - 442.1 ng/mL).These results suggest that this plants and/or their components could lead to the development of new anti-Alzheimer agents.