Antimutagenic activity of essential oils from Schinus areira L. (Anacardiaceae)

RODRIGUEZ, SILVANA; SUEIRO, R.A.; ANA PAULA MURRAY; LEIRO J.M.

New York

Congreso; 2012 International Congress on Natural Products Research (ICNPR); 2012

ASP, SIF, GA, PSE and AFERP

Schinus areiraL. (syn. Schinus molleL. var. areira(L.) DC.) is a native species known by its medicinal value. The essential oils(EOs) of fruits and leaf from S.areira L. and the major compound from fruit oil have been studiedfor their antimutagenic activity. The chemical composition of the oil of the aerial parts of S. areiraobtained by hydrodistillation was determined by GC-MS. Fruit and leaf oils of S. areira were analyzed separately. The experiments were carriedout using the Ames test 1 with Salmonella typhimuriumstrains TA100, TA98, TA102, TA 1535 and TA 1537. The result determined that EOs do not exhibit mutagenic effect, at concentrations between 5 and 0.05 μg/mL. The EOs also showed antimutagenic activity against sodium azide, 9 amine acridine, 2,4,7-trinitro-9-fluorenone and Mitomycin C. The inhibition of the mutagenic effect from leaf and fruit oils ranged from 30.2-78.3% to 37.1-87.9% respectively, in a concentration-dependent manner. The essential oil from S. areira fruit was more active, this could be associated with the presence of myrcene, the main compound in the oil which isreported to have antimutagenic properties.