Xanthine Oxidase Inhibition by Aqueous Extract of Limonium brasiliense (Plumbaginaceae).

SILVANA RODRIGUEZ; ANA PAULA MURRAY; LEIRO J.M.

Conferencia; The 24th International Electronic Conference on Synthetic Organic Chemistry; 2020

Limonium brasiliense (Boiss.) Kuntze (Plumbaginaceae) is a medicinal plant, that ispopularly used in the folk medicine. In this study, we examined XO inhibitory activity of theaqueous fraction of Limonium brasiliense extract, and its polar bioactive constituents, using theenzymatic HX?XO system in vitro. Seven active compounds isolated from the aqueous extract, haveproved to be strong XO inhibitors. Prodelphinidin B1-3,3′-digallate (1), showed the most potentinhibitory activity with an IC50 value of 6.61 μM, comparable to allopurinol. This study providesbases for the potential use of the aqueous fraction of L. brasiliense against hyperuricemia, displayingpotent XO inhibitory activity with an IC50 value of 48.3 μg/mL. This inhibitory effect is compatiblewith the presence of (1) in this extract.