Photochromic Azoderivatives for Acetylcholinesterase Inhibition

BISCUSSI, BRUNELLA; SEQUEIRA, MARIA ALEJANDRA; ANA PAULA MURRAY

Conferencia; The 23rd International Electronic Conference on Synthetic Organic Chemistry; 2019

We present microwave-assisted synthesis and in vitro acetylcholinesterase inhibition of di-PRLC4OAzo, a new azoderivative designed on the basis of aza-stilbene active compounds, already reported by the group. From the total series of azoderivatives synthetized, di-PRLC4OAzo showed the powerful in vitro enzymatic response for its (E) isomer (IC50: 1.08 μM) by Ellman?s assay, beside a stable photostationary state monitored by UV/Vis absorption spectroscopy, indicating itmight be an efficient photo-responsible probe to remote control the activity of the enzyme.