Molecular mechanism underlying acute pancreatitis-induced autophagy

MOLEJON MI; ROPOLO, A; BOGGIO, V; VELENZUELA, G; RITTACO, T; VACCARO, MI

Congreso; 43rd Meeting of the American Pancreatic Association and the 17th Meeting of the International Association of Pancreatology; 2012

We characterized the Vacuole Membrane Protein 1 -VMP1- as an essential autophagy-related transmembrane protein which expression activated autophagy during acute pancreatitis. VMP1 triggers autophagosome formation even under nutrient-replete conditions and its expression