INVESTIGADORES
MOLEJON Maria Ines
artículos
Título:
Chemotherapy and Autophagy-Mediated Cell Death in Pancreatic Cancer Cells
Autor/es:
ROPOLO A; BAGNES C.I.; MOLEJON MI; LO RE A; BOGGIO V; GONZALEZ CD; VACCARO MI
Revista:
PANCREATOLOGY
Editorial:
KARGER
Referencias:
Lugar: Basel; Año: 2011
ISSN:
1424-3903
Resumen:
Autophagy is an evolutionarily preserved degradation process of cytoplasmic cellularconstituents and plays important physiological roles in human health and disease. It hasbeen proposed that autophagy plays an important role both in tumor progression and inpromotion of cancer cell death, although the molecular mechanisms responsible for thisdual action of autophagy in cancer have not beenelucidated.Pancreaticductaladenocarcinoma is one of the most aggressive human malignancies with 2?3% five-yearsurvival rate. Its poor prognosis has been attributed to the lack of specific symptoms andearly detection tools, and its relatively refractory to traditional cytotoxic agents andradiotherapy. Experimental evidence pointed at autophagy as a pancreatic cancer cellmechanism to survive under adverse environmental conditions, or as a defectiveprogrammed cell death mechanism that favors pancreatic cancer cell resistance totreatment. Here, we consider several phenotypical alterations that have been related toincrease or decrease the autophagic process in pancreatic tumor cells. We specially reviewautophagy as a cell death mechanism in response to chemotherapeutic drugs.