INVESTIGADORES
BRECCIA Javier Dario
artículos
Título:
Antitumoral effects of glycoconjugates on primary cultures of human pancreatic cancer cells obtained by echoendoscopy
Autor/es:
MOLEJÓN MI; WEIZ G; TELLECHEA JI; BRECCIA JD; VACCARO MI
Revista:
ACTA GASTROENTEROLOGICA LATINOAMERICANA.
Editorial:
SOCIEDAD ARGENTINA DE GASTROENTEROLOGÍA
Referencias:
Lugar: Buenos Aires; Año: 2019 vol. 49 p. 208 - 221
ISSN:
0300-9033
Resumen:
Pancreatic ductal adenocarcinoma (PDAC), which constitutes 90% of pancreatic cancers, is the fourth leading cause of cancer-related deaths in the world. PDAC belongs to one of the most chemo resistant cancers, in part due to its molecularand genetics features. Currently, available therapeutic options are surgery, radiation, chemotherapy, and immunotherapy. Most of the available treatments are palliative, with the objective of relieving disease-related symptoms. Our aim was to evaluate the antitumoral effect as a second line therapy, of enzymatically glycosylated compounds, hydroquinone-rutinoside, on primary pancreatic tumoral cells. We found that glycoconjugates combined with antitumor agents, such as gemcitabine, improved single-treatment effects. These findings suggest that emerging trends towards glycoconjugates could be a promising approach for cancer therapies.