Colloidal properties of amiodarone in water at low concentration.

LUCIANO BENEDINI; PAULA V. MESSINA; RUBEN H. MANZO; DANIEL A. ALLEMANDI; SANTIAGO D. PALMA; ERICA P. SCHULZ; MARISA A. FRECHERO; PABLO C. SCHULZ

JOURNAL OF COLLOID AND INTERFACE SCIENCE

ACADEMIC PRESS INC ELSEVIER SCIENCE

Año: 2010 vol. 342 p. 407 - 414

0021-9797

Amiodarone aqueous systems at concentrations C 6 3 mg/mL were studied with different techniques (conductivity, solubility, ion-selective electrodes, pH, viscosity, polarizing microscopy, computational simulation, electron microscopy and fluorescence at various temperatures. The Krafft point (TK = 70.6 C) was determined. A partial phase diagram was plotted showing the critical micelle concentration (CMC) dependence on temperature, the solubility and a transition between a coacervate and an unstable gel below TK as a function of temperature. The nature of aggregates below TK at different concentrations was determined. Micellization is an entropy-driven process which is probably caused by a strong dehydration of the amiodarone backbone on micellization. CMC, micelle aggregation number and TK given in earlier literature were misinterpreted in the original articles and are re-interpreted in this work.