INVESTIGADORES
PUETA mariana
congresos y reuniones científicas
Título:
Effects of prenatal ethanol experience upon maternal metabolism and pup/dam interactions during breastfeeding
Autor/es:
M. PUETA, P. ABATE, O.B. HAYMAL, N.E. SPEAR & J.C. MOLINA
Lugar:
Chicago, Illinois, EEUU
Reunión:
Congreso; 30th Scientific Meeting of the Research Society of Alcoholism; 2007
Institución organizadora:
Research Society on Alcoholism
Resumen:
Female rats show
severe disruptions in maternal care when administered with EtOH. These
disruptions are not observed when dams have been previously exposed to the drug
during late gestation. Two experiments were conducted to evaluate possible
metabolic changes resulting from EtOH exposure during late pregnancy that can
mitigate subsequent behavioral alterations during breastfeeding. The impact of
ethanol exposure during gestation and nursing was also evaluated in terms of
infantile nursing processes. In both experiments pregnant rats were treated
with EtOH (1 or 2 g/kg, i.g.) or water during gestational days 17-20 and latter
challenged (postnatal day 3) with a subnarcoleptic EtOH dose (2.5 g/kg, i.g.).
In Experiment 1, maternal BECs were assessed at PD 3 at 5, 15, 30, 75, 120 and
240 min. postadministration times. Prenatal experiences with EtOH were found
not to affect pharmacokinetic processes during early nursing. Experiment 2
examined the impact of EtOH exposure during late gestation upon infantile milk
intake in a nursing bout defined by the context of maternal EtOH intoxication.
All dams received a 2.5 g/kg EtOH dose and pups were allowed to suckle from
their mother for a 45-min interval. Pups that suckled from a dam with prior
EtOH experience gained significantly more weight than did infants suckling from
an intoxicated mother that received water during gestation. The latter pups
practically showed no body weight gains. These results indicate that behavioral
tolerance to EtOH in dams exposed to the drug during late gestation is not
dependent upon metabolic changes. The results also indicate that EtOH
intoxication during the breastfeeding period has a deleterious effect upon
infantile nursing processes which is partially reversed when dams have
previously experienced the drug. Apparently, late gestational experience with
EtOH results in subsequent behavioral or physiological development of ethanol
tolerance which permits availability of milk contaminated with ethanol or
resistance to the drugs disruptions in maternal care.