INVESTIGADORES
MALCHIODI Emilio Luis
artículos
Título:
In vitro evaluation of antiprotozoal and antiviral activities of extracts from Argentinean Mikania species.
Autor/es:
LAURELLA LC; FRANK FM; SARQUIZ A; ALONSO MR; GIBERTI G; CAVALLARO L; CATALÁN CA; CAZORLA SI; MALCHIODI EL; MARTINO VS; SÜLSEN VP
Revista:
SCIENTIFIC WORLD JOURNAL, THE
Editorial:
THESCIENTIFICWORLD LTD
Referencias:
Lugar: New York; Año: 2012 p. 1 - 12
ISSN:
1537-744X
Resumen:
The aim of this study was to investigate the antiprotozoal and antiviral activities of four Argentinean Mikania species. The organic and aqueous extracts of Mikania micrantha, M. parodii, M. periplocifolia and M. cordifolia were tested on epimastigotes of Trypanosoma cruzi, on promastigotes of Leishmania braziliensis and on dengue virus type 2. The organic extract of M. micrantha was the most active against T. cruzi and L. braziliensis with growth inhibitions of 77.59±4.47% and 84.86±6.11%, respectively at a concentration of 10 µg/ml. None of the tested extracts were active against dengue virus type 2. The bioguided fractionation of M. micrantha organic extract led to the identification of two active fractions. The chromatographic profile and infrared analysis of these fractions revealed the presence of sesquiterpene lactones.