Rol de galectina 1 en la fisiología de las enfermedades inflamatorias gastrointestinales

PAPA GOBBI, R; ROCCA, A; SAMBUELLI, A.; YANTORNO, M; TOSCANO, M.; MUGLIA, C. I.; RABINOVICH, G.; DOCENA, G.

Los Cocos, Córdoba

Congreso; LXI Reunión Anual de la Sociedad Argentina de Inmunología; 2013

Sociedad Argentina de Inmunología

Inflammatory bowel diseases (IBD) are multifactorial disorders characterized by a chronic intestinal inflammation. Galectin-1, a ubiquitous endogenous lectin, has been implicated in several chronic inflammatory disorders. We aimed to analyze its role in the colonic mucosa of patients with Crohn´s disease (CD) and Ulcerative colitis (UC). Gal-1 expression was studied by qPCR, immunoblotting and histology in biopsies and resected tissues of patients with IBD (n=26) and control patients (n=20). Gal-1-specific binding ligands were also analyzed by flow cytometry in lamina propria and its physiologycal role in the induction of cell death was evaluated by flow cytometry. We found in 21 biopsies of CD and 22 biopsies of CU that expression of Gal-1 was increased in colonic inflamed areas (p