Biodistribution of magnetic nanoparticles functionalized with chitosan intended for drug delivery systems

MARIELA AGOTEGARAY; PAMELA AZCONA; ROBERTO ZYSLER; VIRGINIA MASSHEIMER; ADRIÁN CAMPELO; ALEJANDRA MINETTI; FERNANDA GUMILAR; VERONICA LASSALLE

Congreso; 8vo Congreso Latinoamericano de órganos, biomateriales e Ingeniería de tejidos; 2014

Nanoparticles are described as materials with three external equal nanoscale dimensions. Magnetic nanoparticles (MNPs) present the special characteristic related to the feasibility of external manipulation under the influence of a magnetic field. An interesting and promising application lies in the use of MNPs as drug targeted delivery systems by directing the drug to the desired part of the body. This would avoid side effects associated to the free form of the drug, increasing circulation times, reducing doses and toxicity.Two magnetic nanodevices intended fortargeted drug delivery systems were assessedin mice to study their tissue distribution after asubacute exposure. Citotoxicity has beenevaluated in endothelial cells cultures.Formulations consist of a magnetic coreof magnetite functionalized witholeic acid and recovered with crosslinkedand non-crosslinked chitosan.(N1 and N2, respectively).