INVESTIGADORES
LASSALLE veronica Leticia
congresos y reuniones científicas
Título:
Magnetic nanocarriers with potential applications
Autor/es:
MARIELA AGOTEGARAY; SANTIAGO PALMA; VERÓNICA LASSALLE
Reunión:
Congreso; IV Congreso Argentino de Materia Blanda; 2012
Resumen:
The controlled release of drugs from nanoparticles (NPs) is in attracting increasing attention because of the promising opportunities they provide in the biomedical field. In special, magnetic nanoparticles (MNPs) are of great interest because their magnetic properties enable these particles to be employed in numerous biomedical applications such as diagnosis, anti-cancer therapy and drug delivery (Arruebo et al., 2007). Magnetic vectors can be directed by means of a magnetic field gradient towards a certain location such as in the case of targeted drug delivery (Jurgons et al., 2006). They consist of a metal or metallic oxide core, encapsulated in an inorganic or a polymeric coating that renders the particles biocompatible, stable, and may serve as a support for biomolecules. Diclofenac, a NSAID widely used for the treatment of inflammatory diseases was selected as model drug. The limitations associated to Diclofenac treatment lie in its short biological half-life, pre-systemic metabolism and several side effects (Saravanan et al., 2004). By this way, in this work we have developed a novel magnetic device consisting of magnetite (Fe3O4, MG), oleic acid (OA), chitosan (CS) and glutaraldehide (GA) to be employed for Diclofenac targeted delivery aiming to minimize the side effects associated to the drug.