INVESTIGADORES
LASSALLE veronica Leticia
congresos y reuniones científicas
Título:
NANOCOMPOSITES WITH MAGNETIC RESPONSE FOR THE SUSTAINED RELEASE OF MODEL PROTEINS
Autor/es:
JIMENA GONZÁLEZ; VERÓNICA LASSALLE; VERA ALVAREZ
Reunión:
Simposio; Simposio Argentino de Polímeros; 2011
Resumen:
Stimuli-sensitive polymers are materials that respond to temperature, light, pH, ionic strength or electric and magnetic fields, producing a desired effect such as a discontinuous change in optical or mechanical behavior, surface properties, or in volume or shape (Liu et. al., 2009). A way to obtain these devices is to disperse nanostructures in a polymer gel to form a nanocomposite hydrogel. In general terms, nanocomposite hydrogels may be defined as crosslinked polymer networks, modified with nanoparticles (NPs), swollen with water or biological fluids. Nanoparticles add unique physical properties to polymer hydrogels for electronics, optics, drug delivery, and other biotechnological applications(Schexnailder et. al, 2009). Controlled drug release provides advantages over conventional routes of drugs administration such as major delivery efficiency and site-specific therapy. It has been demonstrated that PVA-coated superparamagnetic iron oxide NPs can serve as delivery system for drug targeting in synovial membrane tissue, as they are taken up intracellularly both, in vitro and in vivo (Hatakeyema et. al., 2009). Ferrogels with different NPs sizes showed different release rates even though they possessed the same concentration of nanomagnets. The aim of this work was to obtain, characterize and apply ferrogels in adsorption and controlled release of proteins. For this purpose, ferrogels composed of PVA and magnetite (iron oxide: Fe3O4) NPs of different characteristics and sizes were synthesized by two different routes: i.by “in-situ” precipitation of iron oxides and;ii. by adding NPs coated by chitosan (CS). The obtained biomaterials were tested for the adsorption of bovine serum albumin (BSA), which was selected as model protein.