INVESTIGADORES
LASSALLE veronica Leticia
artículos
Título:
Nanoparticulated Systems Based on Natural Polymers Loaded with Miconazole Nitrate and Lidocaine for the Treatment of Topical Candidiasis
Autor/es:
G.TEJADA; M.BARRERA; P.GARCIA; M.SORTINO; M.CLAMAS; V.LASSALLE; V.ALVAREZ; D.LEONARDI
Revista:
AAPS PHARMSCITECH
Editorial:
SPRINGER
Referencias:
Lugar: Berlin; Año: 2020 vol. 21
ISSN:
1530-9932
Resumen:
Abstract. People with weakened immune systems are at risk of developing candidiasis10 which is a fungal infection caused by several species of Candida genus. In this work,11 polymeric nanoparticles containing miconazole nitrate and the anesthetic lidocaine12 clorhydrate were developed. Miconazole was chosen as a typical drug to treat13 buccopharyngeal candidiasis whereas lidocaine may be useful in the management of the14 pain burning, and pruritus caused by the infection. Nanoparticles were synthesized using15 chitosan and gelatin at different ratios ranging from 10:90 to 90:10. The nano-systemsQ4 16 presented nanometric size (between 80 and 300 nm in water; with polydispersion index17 ranging from 0.120 to 0.596), and positive Z potential (between 20.11 and 37.12 mV). The18 determined encapsulation efficiency ranges from 65 to 99% or 34 to 91% for miconazole19 nitrate and lidocaine clorhydrate, respectively. X-ray diffraction and DSC analysis suggested20 that both drugs were in amorphous state in the nano-particles. Finally, the systems fitted best21 the Korsmeyer?Peppas model showing that the release from the nanoparticles was through22 diffusion allowing a sustained release of both drugs and prolonged the activity of miconazole23 nitrate over time against Candida albicans for at least 24 h.