INVESTIGADORES
LASSALLE veronica Leticia
artículos
Título:
Hybrid nanomaterials based on gum Arabic and magnetite for hyperthermia treatments
Autor/es:
MARÍA FERNANDA HORST; DIEGO CORAL; MARCELA FERNANDEZ VAN RAAP; MARIANA ALVAREZ; VERÓNICA LASSALLE
Revista:
MATERIALS SCIENCE & ENGINEERING. C, BIOMIMETIC MATERIALS, SENSORS AND SYSTEMS
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Lugar: Amsterdam; Año: 2016
ISSN:
0928-4931
Resumen:
In this study, one?step co-precipitation method was conveniently adapted to obtain novelnanomaterials based on Gum Arabic and magnetite. Two synthesis procedures were evaluated:one employing the solid biopolymer in the co-precipitation media; a second using an aqueoussolution of the polysaccharide. An exhaustive characterization of both formulations wasperformed using several specific techniques. The obtained data confirmed the successfulincorporation of the gum Arabic on the magnetic core. Values of hydrodynamic diameters,measured by dynamic light scattering, in aqueous dispersions were about 70-80 nm, while sizeslower than 20 nm were registered by TEM microscopy. Surface charge of gum Arabic coatedmagnetic nanoparticles was significantly different from the corresponding to raw materials(magnetite and GA). This fact confirmed the formation of hybrid nanosystems with novel andspecific properties.The potential utility of these materials was tested regarding to magnetic hyperthermia therapyunder radiofrequency fields. Magnetocalorimetric measurements were performed in a widerange of field amplitude and frequency. Specific absorption rate of 218 W/gFe was determinedat field frequency of 260 kHz and amplitude of 52 kA/m. These results demonstrate theirviability to be applied in tumour ablation treatments. Using the linear response theory andrestricting field parameters to the accepted biomedical window, maximum useful value of 74w/gFe is predicted at 417 kHz and 12 kA/m.