Does the Arterial Flow Rate affect Flow Diverter Stent Performance?

H. MORALES; O. BONNEFOUS; A. J. GEERS; O. BRINA; V. MENDES PEREIRA; L. SPELLE; J. MORET; I. LARRABIDE

AMERICAN JOURNAL OF NEURORADIOLOGY

AMER SOC NEURORADIOLOGY

Lugar: New York; Año: 2016 vol. 31 p. 2293 - 2298

0195-6108

BACKGROUND AND PURPOSE: To assess the performance of flow diverter stents, the pre-and end-of-treatment angiographies are commonly used. However, the arterial flow rate maychange between acquisitions and therefore, a better understanding of its influence on the localintra-aneurysmal hemodynamics before and after flow diverters is required.MATERIAL AND METHOD: 25 image-based aneurysm models extracted from 3DRA imageswere conditioned for computational fluid dynamic simulations. Pulsatile simulations wereperformed at different arterial flow rates, covering a wide physiological range. The effect of flowdiverter stents on intra-aneurysmal hemodynamics was numerically simulated with a porous) was calculatedmedium model. Spatiotemporal averaged intra-aneurysmal flow velocity (‫݈݁ݒ‬for each case and flow rate to quantify the hemodynamics after treatment. The short-term flowdiverter performance was characterized by the relative velocity reduction ( ‫ݒ‬ ௥௘ௗ ) inside theaneurysm.തതതതത ௦௔ before and after flow diverter linearly increases when the mean arterial flowRESULTS: ܸ݈݁rate rises (minimum R 2 >0.983 of the linear regression models for untreated and stented models).ܸ ௥௘ௗ decreases when increasing arterial flow rates. However, when the physiological range ofarterial flow rate is considered, i. e., between 4 ml/s ±1 ml/s, then mean SD of ‫ݒ‬ ௥௘ௗ was reducedfrom 3.6% to 0.48%.CONCLUSIONS: Flow diverter performance does depend on the arterial flow rate. However, theperformance can be considered as independent of the arterial flow rates within (or above) thephysiological range.