Evaluation of the Abamectin plus Oxfendazole Combination to Control Resistant Nematodes in Cattle

CANTÓN, CANDELA; MILLER, C.; CEBALLOS, LAURA; DOMINGUEZ, PAULA; WAGHORN, T. ; LANUSSE, CARLOS EDMUNDO; ALVAREZ, LUIS IGNACIO; LEATHWICK, D.

Dublin

Congreso; 28º Conference of the World Association for the Advancement of Veterinary Parasitology WAAVP; 2021

The current study evaluated the efficacy and the potential pharmacokinetic(PK) interactions occurring after the oral administration of abamectin(ABA) and oxfendazole(OXF) given both separately and co-administered to calves in two farms(A and B). On each farm sixty(60) male calves infected with gastrointestinal nematodes were randomly allocated into four groups(n= 15): Control: animals did not receive anthelmintic treatment; ABA: treated with ABA(0.2 mg/kg); OXF: treated with OXF(4.5 mg/kg); ABA+OXF: simultaneously treated with ABA and OXF(at the above doses). Seven(7) animals from each treated group(from Farm B) were randomly selected to perform the PK study with blood samples being taken from these animals at regular intervals. A significantly(P