EFFECTS OF FEEDING ON THE PLASMA DISPOSITION KINETICS OF THE ANTHELMINTIC ALBENDAZOLE IN LAYING HENS

BISTOLETTI, M; ALVAREZ L,; LANUSSE, C; MORENO, L

BRITISH POULTRY SCIENCE

TAYLOR & FRANCIS LTD

Lugar: Londres; Año: 2014

0007-1668

1. To optimize the use of ABZ as an anthelmintic in hens, the effects of fasting and type of diet on the 30 plasma kinetics of ABZ and its metabolites were evaluated. 31 2. Twenty four hens were distributed into four groups: Experiment I: Fed-group fed ad libitum; 32 Fasted-group was fasted over a 12 h period. Experiment II: Pelleted-group fed with pelleted 33 commercial food; Grain-group fed with cereal grains. All groups were treated with ABZ by oral route. 34 Blood samples were taken and plasma analysed by HPLC. 35 3. ABZ and its metabolites ABZSO and ABZSO2 were recovered in plasma in all the groups. The 12 h 36 fasting period did not modify the disposition kinetics of ABZ in hens. The type of feed affected ABZ 37 kinetics. ABZSO concentration profile was higher and detected longer in the Grain-group compared to 38 the Pelleted-group. Statistical differences were not found for AUC0-∞ values, meanwhile the T1/2for and 39 T1/2el were different between groups. 40 4. Factors affecting ABZ kinetic behaviour should be considered to optimise its use to ensure the 41 sustainability of the limited available anthelmintic therapeutic tools in avian parasite control.