INVESTIGADORES
BARBEITO ANDRES jimena
artículos
Título:
Congenital Zika syndrome is associated with maternal protein malnutrition
Autor/es:
BARBEITO - ANDRÉS, J.; PEZZUTO, P.; HIGA, L. M.; DIAS, A. A.; VASCONCELOS, J. M.; SANTOS, T. M. P.; FERREIRA, J. C. C. G.; FERREIRA, R. O.; DUTRA, F. F.; ROSSI, A. D.; BARBOSA, R. V.; AMORIM, C. K. N.; DE SOUZA, M. P. C.; CHIMELLI, L.; AGUIAR, R. S.; GONZALEZ, P. N.; LARA, F. A.; CASTRO, M. C.; MOLNÁR, Z.; LOPES, R. T.; BOZZA, M. T.; VIANEZ, J. L. S. G.; BARBEITO, C. G.; CUERVO, P.; BELLIO, M.; TANURI, A.; GARCEZ, P. P.
Revista:
Science Advances
Editorial:
AAAS
Referencias:
Año: 2020 vol. 6
Resumen:
Zika virus (ZIKV) infection duringpregnancy is associated with a spectrum of developmental impairments known as congenital Zika syndrome (CZS). Theprevalence of this syndrome varies across ZIKV endemic regions, suggesting thatits occurrence could depend on cofactors. Here, we evaluate the relevance ofprotein malnutrition for the emergence of CZS. Epidemiological data from theZIKV outbreak in the Americas suggest a relationship between undernutrition andcases of microcephaly. To experimentally examine this relationship, we useimmunocompetent pregnant mice, which were subjected to protein malnutrition andinfected with a Brazilian ZIKV strain. We found that the combination of proteinrestriction and ZIKV infection leads to severe alterations of placentalstructure and embryonic body growth, with offspring displaying a reduction inneurogenesis and postnatal brain size. RNA-seq analysis reveals gene expressionderegulation required for brain development in infected low-protein progeny.These results suggest that maternal protein malnutrition increasessusceptibility to CZS.