Structural Factors of Annonaceous Acetogenins and Their Semisynthetic Analogues Related with the Toxicity on Spodoptera frugiperda

LILIAN DI TOTO BLESSING; FLORENCIA BUDEGUER; JUAN RAMOS; BARDON, ALICIA DEL VALLE; SONIA DIAZ; MARGARITA BROVETTO; GUSTAVO SEOANE; ADRIANA NESKE

Journal of Agricultural Chemistry and Environment

Scientific Research Publishing

Año: 2015 vol. 4 p. 56 - 61

Toxic and nutritional effects of annonaceous acetogenins and their semisynthetic analogues onSpodoptera frugiperda were evaluated. Structural modification of the natural ACG, blocking the OHflanking THF with MOM, allowed us to suggest the mode of action of ACG in the membrane. Ourstudy emphasizes the role of the flanking OH and acetyl groups of THF with the membrane hydrophilicpolar head groups. They are essential structural factors in the ACG that facilitate the intermolecularinteraction that dehydrates the membrane and makes it potentially toxic against Spodopterafrugiperda.