Interaction of S-methyl methanethiosulfonate with DPPC bilayer

M. E. DEFONSI LESTARD ; S. B. DÍAZ ; M. E. TUTTOLOMONDO ; S. SÁNCHEZ CORTEZ ; M. PUIATTI ; A. B. PIERINI ; A. BEN ALTABEF

SPECTROCHIMICA ACTA A: MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

ELSEVIER

Lugar: Amsterdam ; Año: 2012 vol. 97 p. 479 - 489

0584-8539

The present study is a first step towards the investigation of S-methyl methanethiosulfonate (MMTS) interaction with membrane model systems like liposomes. In this paper, the interaction of MMTS with dipalmitoylphosphatidylcholine (DPPC) bilayers was studied by FTIR and SERS spectroscopy. Lysolipid effect on vesicle stability was studied. The results show that MMTS interacts to different extents with the phosphate and carbonyl groups of membranes in the gel and the liquid crystalline states. To gain a deeper insight into MMTS properties that may be potentially helpful in the design of new drugs with therapeutic effects, we performed theoretical studies that may be the basis for the design of their mode of action.